Interaction of various types of bisphenols with enzymes involved in melanin synthesis

Bisphenol is one of the commercial chemical compounds which finds application in manufacture phenol, polyesters, polycarbonates, epoxy resins, etc. A most commonly found bisphenol derivative, although there are various analogues such as S, B, C, E, AF, vary with their structures. Bisphenols majorly get into us by means food they packaging and beverage containers can be easily absorbed body. They make way body systems either direct like skin contact or indirect through that stored a bisphenol-coated containers. Exposure human system to this compound may bring about mild adverse ailments ranging from irritations infertility. Pigmentation disorder health condition occurs due melanocyte destruction caused exposures. interact proteins enzymes have been involved synthesis pathway, thereby disrupting normal functions. In silico analysis has done predict interaction other descriptive binding parameters when derivatives BPA. BPB, BPC, BPE, BPS BPAF docked some essential for melanin tyrosinase, tyrosinase-related protein 1(TRP-1), dopachrome tautomerase/tyrosinase-related protein-2(TRP-2). The quantified energies, interacting amino acid residues also identified. results showed strong interactions both TRP-1 TRP-2 BPAF. risk threats products made at higher levels, thereby, need safe desirable alternative insisted.